PREVENTION OF PHORBOL MYRISTATE ACETATE-INDUCED ACUTE LUNG INJURY BY ALPHA-TOCOPHEROL LIPOSOMES

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Authors
  1. Suntres, Z.E.
  2. Shek, P.N.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
Phorbol myristate acetate (PMA) is commonly used to produce experimental edema and other tissue injuries in the lung. Lung injuries induced by teh administration of PMA has been shown to be mediated mainly by neutrophils. Neutrophils recruited to the lower respiratory tract may damage lung tissues by releasing reactive oxygen species, neutral proteases, and lysosomal enzymes. The present study was conducted to investigate whether alpha-tocopherol, entrapped in dipalmitoylphosphatidylcholine liposomes and delivered directly to the lung, cold counteract some of the PMA-induced lung injuries. Plain liposomes of alpha-tocopherol containing liposomes (8 mg alpha-tocopherol/kg body weight.) were intratracheally instsilled into the lungs of rats 24 hr prior to PMA exposure (25 mu g/kg) and treated rats were killed 3 hr later. Lung sof control animals exposed to PMA developed an increase in lung weight and lipid peroxidation as well as a decrease inlung angiotensin converting enzyme (ACE) and alkaline phosphatase (AKP) activities.
Keywords
Drug delivery;Phorbol myristate acetate (PMA)
Report Number
DCIEM-95-09 — Reprint
Date of publication
01 Mar 1995
Number of Pages
8
Reprinted from
Journal of Drug Trageting, vol 3, 1995, p 201-208
DSTKIM No
96-02281
CANDIS No
498778
Format(s):
Document Image stored on Optical Disk;Hardcopy

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