INFLUENCE OF GRANISETRON ON THERMOREGULATION DURING EXERCISE IN THE HEAT

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Authors
  1. McLellan, T.M.
  2. Ducharme, M.B.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
A NATO project group has an interest in selecting an antiemetic agent that not only is effective in the prevention of emesis induced by chemical agents or radiation exposure but also has minimal if any, side effects. Granisetron is the second candidate drug of a class of selective serotonin antagonists that has been shown to be an effective antiemetic agent for patients receiving radiation or chemotherapy treatment. The present study was designed to evaluate whether a single 2-mg oral dose of granisetron influenced temperature regulation during exercise in a hot and relatively dry environment. For the environmental conditions used in this investigation, we would accept the null hypothesis that a single 2 mg oral dose of granisetron does not influence temperature regulation during exercise.
Keywords
Granisetron;Antiemetic agents
Report Number
DCIEM-95-15 — Reprint
Date of publication
30 May 1996
Number of Pages
5
Reprinted from
Aviation, Space, and Environmental Medicine, vol 67, no 5, 1996, p 453-457
DSTKIM No
96-02592
CANDIS No
498828
Format(s):
Document Image stored on Optical Disk;Hardcopy

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