NATO PANEL VII/SICA INTERNATIONAL TRAINING EXERCISE ON THE IDENTIFICATION OF PEPTIDES

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Authors
  1. Hancock, J.R.
  2. D'Agostino, P.A.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
The revision of the Terms of Reference for NATO's Sampling and Identification of Chemical/Biological Agents (SICA) subgroup to include the entire CB agent spectrum and the current lack of analytical methods for mid-spectrum agents prompted SICA to hold an international training exercise focussing on the identification of these agents. From the 11 NATO countries represented on the SICA subpanel, laboratories from Canada (host nation), Denmark, Netherlands, Norway, United Kingdom and United States (2 laboratories) agreed to participate in the international training exercise. The objective of the exercise was to evaluate the basic capabilities of the laboratories to determine molecular weights and primary amino acid sequences for five unknown peptides with molecular weights in the same mass range as many mid-spectrum agents. The determination of an unknown's molecular weight is considered to be one of the initial steps in the identification of a mid-spectrum agent. All the participating laboratories demonstrated the basic ability to determine either monisotopic or average molecular weights for the unknown peptide samples. The most accurate results, with an average error of 9.2 ppm, in this part of the training exercise were reported by Canada, using electrospray ionization interfaced to a high resolution mass spectrometer. TRUNCATED
Report Number
DRES-M-1481 — Memorandum
Date of publication
01 Sep 1996
Number of Pages
21
DSTKIM No
96-03766
CANDIS No
500194
Format(s):
Hardcopy;Document Image stored on Optical Disk

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