DISRUPTIONS IN THE SECRETION OF CORTISOL, PROLACTIN, AND CERTAIN CYTOKINES IN HUMAN AFRICAN TRYPANOSOMIASIS PATIENTS

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Authors
  1. Radomski, M.W.
  2. Buguet, A.
  3. Bogui, P.
  4. Doua, F.
  5. Lonsdorfer, A.
  6. and others
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
It has been shown previously that sleeping sickness at the stage of meningoencephalitis manifests itself as a significant disturbance in the circadian rhythm of sleep-wakefulness. The objective of the current study was to examine the extent of circadian disruption in infected patients by measuring 24 hours patterns of plasma cortisol, an example of a classical circadian rhythm relatively independent of sleep, and prolactin, a primarily sleep-related rhythm. Plasma levels of certain cytokines were also measured to examine the immunopathogenesis of human African trypanosomiasis. An attempt was made to relate any circadian disruptions to the severity of the disease. The three most advanced patients demonstrated circadian disruptions in cortisol, prolactin and sleep-wake rhythms. The prime cytokine factor that correlated with the progression of the disease in humans was interferon-gamma, levels being 7- to 12-fold higher in the patients without any circadian rhythms. Our findings support the hypothesis that human African trypanosomiasis induces selective changes in the suprachiasmatic nucleus, important as a pacemaker for biological rhythms, resulting in disruptions of circadian rhythmicity in advanced stages of the disease.
Keywords
Sleeping sickness;Cytokines
Report Number
DCIEM-96-RP-61 — Reprint
Date of publication
01 Aug 1996
Number of Pages
5
Reprinted from
Bull Soc Path Ex, vol 87, 1994, p 376-379
DSTKIM No
97-00088
CANDIS No
500327
Format(s):
Hardcopy;Document Image stored on Optical Disk

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