ALLEVIATION OF PARAQUAT-INDUCED LUNG INJURY BY PRETREATMENT WITH BIFUNCTIONAL LIPOSOMES CONTAINING ALPHA-TOCOPHEROL AND GLUTATHIONE

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Authors
  1. Suntres, Z.E.
  2. Shek, P.N.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
Reactive oxygen species are known to play a key role in the development of acute lung injury, and such injury can be alleviated by pretreating the lung with a suitable antioxidant preparation. In this study, we evaluated and compared the antioxidant efficacy of two liposomal preparations: liposomes containing only alpha-tocopherol versus bifunctional liposomes containing both alpha-tocopherol and glutathione (GSH), alpha-Tocopherol liposomes (2 mg alpha-tocopherol/animal) or liposomes containing both alpha-tocopherol and GSH (2 mg alpha-tocopherol and 10 mu mol GSH/animal) were intratacheally instilled into the lungs of rats 30 min prior to a challenge with paraquat dichloride (30 mg/kg, i.p.); animals were killed 24 hr post-paraquat challenge. Lungs of paraquat-challenged animals were damage extensively as evidenced by increases in lung weight, indicative of edema, and decreases in lung activities of angiotensin coverting enzyme (ACE) and alkaline phosphatase (AKP), indicative of endothelial and alveolar type II epithelial cell injuries, respectively. TRUNCATED
Keywords
Paraquet;Bifunctional liposomes
Report Number
DCIEM-P-95-51 — Reprint
Date of publication
26 Mar 1996
Number of Pages
6
Reprinted from
Biochemical Pharamacology, vol 52, 1996, p 1515-1520
DSTKIM No
96-03763
CANDIS No
500387
Format(s):
Hardcopy;Document Image stored on Optical Disk

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