THE PULMONARY UPTAKE OF INTRAVENOUSLY ADMINISTERED LIPOSOMAL ALPHA-TOCOPHEROL IS AUGMENTED IN ACUTE LUNG INJURY

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Authors
  1. Suntres, Z.E.
  2. Shek, P.N.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
The present study was carried out to investigate whether the intravenous administration of liposomal alpha-tocopherol can result in a significant localization of the antioxidant in the injured lung. Male Sprague-Dawley rats were injected with paraquat dichloride (20 mg/kg, ip.) and 4, 24 or 48 h later, they were given an intravenous injection of a liposomal alpha-tocopherol preparation (20 mg alpha-tocopherol in 128 mu moles liposomal lipid/kg) labeled with (14C) dipalmitoylphosphatidylcholine (DPPC) and (3H) alpha-tocopherol. Animals were killed and their lungs removed from analysis 24 h after liposomal treatment. To demonstrate whether the extent of uptake of radioactive alpha-tocopherol liposomes were directly related to the extent of residual lung injury, additional groups of animals were also injected with higher doses (30 and 40 mg/kg body weight) of paraquat dichloride and 48 h later, were treated with liposomal alpha-tocopherol; animals were then killed 24 h after liposomal alpha-tocopherol treatment. The intraperitoneal injection of paraquat dichloride resulted in time- and dose-dependent decreases in angiotensin converting enzyme and alkaline phosphatase activities suggesting that the toxicant injures both the capability endothelial cells and alveolar type II epithelial cells, respectively. TRUNCATED
Keywords
Paraquat;Oxidant-induced tissue damage;Drug delivery;Lung injuries
Report Number
DCIEM-96-RP-04 — Reprint
Date of publication
30 Apr 1996
Number of Pages
10
Reprinted from
Journal of Drug Targeting, vol 4, no 3, 1996, p 151-159
DSTKIM No
97-01241
CANDIS No
501519
Format(s):
Hardcopy;Document Image stored on Optical Disk

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