TOXIN DETECTION BY ION MOBILITY SPECTROMETRY

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Authors
  1. Kim, L.
  2. Cacciacarro, L.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN);Barringer Research Ltd, Mississauga ONT (CAN)
Abstract
The objective of this project was to investigate IONSCAN signatures of toxin simulants which have the representative characteristics of real toxins. IONSCAN is a chemical detector system based on Ion Mobility Spectrometry. Twenty-two toxin simulants as suggested by DRES scientific authority were selected. The selected toxins simulants have characteristics of real toxins in terms of their particle size and chemical structure, lacking only the toxic properties. All twenty-two compounds were tested of which twenty-one were easily detected by IONSCAN under various conditions. Three representative toxins; Substance P, Lens Culnaris and 6-o-alpha-L-fucopyranosyl-N,N'-diacetylchitobiose were selected and the IONSCAN operating parameters were optimized for best sensitivity. One set of control parameters was then selected to obtain the best sensitivity for all three substances. At the optimum operating conditions, the IONSCAN detection limits of Substance P, Lens Culnaris and 6-o-alpha-L-fucopyranosyl-N-N'-diacetylchitobiose were determined to be 50, 375 and 50 ng, respectively. The plasmagrams of the three substances under the selected control parameters had different ion peaks such that each had its unique detection algorithm making speciation by IONSCAN possible. The remaining eighteen toxin simulants when run under the same detection conditions could also be identified correctly.
Keywords
Toxin signatures;Ion Mobility Spectrometry (IMS)
Report Number
DRES-CR-97-29 — Contractor Report (Final)
Date of publication
01 Mar 1997
Number of Pages
60
DSTKIM No
97-04039
CANDIS No
505136
Format(s):
Hardcopy;Document Image stored on Optical Disk

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