GRANISETRON SHOWS NO PRO-ARRHYTHMIC EFFECT IN NORMAL SUBJECTS DURING OR AFTER EXERCISE IN A HOT ENVIRONMENT

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Authors
  1. Gray, G.W.
  2. McLellan, T.M.
  3. Ducharme, M.B.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
5-HT3 receptor antagonists are being evaluated as possible agents to prevent nausea and vomiting associated with radiation exposure in a non-clinical military setting. Because of concern about potential cardiovascular toxicity and the observation that certain developmental 5-HT3 antagonists produced undesirable effects, all drugs in this class are being carefully scrutinized for possible adverse cardiac effects. In this study, nine subjects underwent ambulatory ECG monitoring for an average of 21.6 hours after a 2 mg oral dose of granisetron or placebo in a double-blind crossover protocol. Monitoring included a three hour period of submaximal exercise in a 40C environment. Although isolated ventricular and supraventricular ectopic activity, sinus bradycardia, and pauses were a common finding, there were no sustained arrhythmias observed in either the placebo or granisetron conditions. These observations add to the body of evidence confirming the lack of cardiovascular toxicity of granisetron.
Keywords
Granisetron;5-HT3 antagonists;Ambulatory ECG monitoring
Report Number
DCIEM-95-P-23 — Reprint
Date of publication
01 Jul 1995
Number of Pages
5
Reprinted from
Aviation, Space, and Environmental Medicine, vol 67, no 8, 1996, p 759-761
DSTKIM No
98-00088
CANDIS No
506685
Format(s):
Hardcopy;Document Image stored on Optical Disk

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