THE EFFECT OF MODAFINIL AND AMPHETAMINE ON CORE TEMPERATURE AND COGNITIVE PERFORMANCE USING COMPLEX DEMODULATION DURING 64 HOURS OF SUSTAINED WORK

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Authors
  1. Pigeau, R.
  2. Naitoh, P.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
Modafinil (diphenylmethyl-sulfinyl-2 acetamide) is an alerting substance that is considered safer than amphetamine with fewer side effects. It appears to produce no feelings of euphoria, does not seem to be addicting, induces no drug tolerance and in large dosage (>4500 mg) does not produce serious medicla problems. These features make a modafinil a good candidate to reduce or ameliorate the effects of prolonged sleep loss in military operations. The validity of these claims, however, is in question due to the very few number of controlled studies using normal adult subjects. Modafinil has been used primarily in either clinical studies to treat sleeping disorders or in animal studies to investigate its pharmacological properties. Modafinil is described as an alpha-1 adrenergic agonist, but Mignot et al. have recently questioned this interpretation, reporting that modafinil had good selectivity for the dopaminergic transporter. Nevertheless, the relatively benign psycho-pharmacological properties of modafinil make it a good candidate to reduce or ameliorate the cognitive effects of prolonged sleep loss under continuous workoad conditions. Presently, use of modafinil in Canada is limited to scientific and/or clinical investigations.
Keywords
Modafinil;Sustained operations
Report Number
DCIEM-95-36 — Paper
Date of publication
01 Oct 1995
Number of Pages
13
DSTKIM No
98-00091
CANDIS No
506688
Format(s):
Hardcopy;Document Image stored on Optical Disk

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