THE EFFECTS OF MODAFINIL, D-AMPHETAMINE, AND PLACEBO ON PHYSIOLOGICAL AND PSYCHOLOGICAL STRESS DURING SLEEP DEPRIVATION

PDF

Authors
  1. Shek, Y.
  2. Pigeau, R.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
Two methods were used to measure the effects of two drugs for alleviating stress due to sleep loss. The two drugs were: modafinil and d-amphetamine (vs. placebo). The first method was the NASA Task Load Index (TLX), a subjective measure of workload. The second was a physiological measure to salivary cortisol levels. The NASA TLX was found insensitive to drug conditions and showed no significant variation over time. Subjects who were given d-amphetamine had significantly higher salivary cortisol levels than subjects who were given placebo or modafinil. Salivary cortisol levels varied with the circadian cycle, peaking at 0730 hours for each of the sleep loss days. There was no correlation between the TLX scores and salivary cortisol leels (r = .05).
Keywords
Modafinil;Sustained operations
Report Number
DCIEM-95-P-45 — Paper
Date of publication
01 Oct 1995
Number of Pages
8
DSTKIM No
98-00095
CANDIS No
506696
Format(s):
Hardcopy;Document Image stored on Optical Disk

Permanent link

Document 1 of 1

Date modified: