PACKED CAPILLARY LIQUID CHROMATOGRAPHY ELECTROSPRAY MASS SPECTROMETRY AND TANDEM MASS SPECTROMETRY OF HYDROLYSED HT AND HQ

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Authors
  1. D'Agostino, P.A.
  2. Provost, L.R.
  3. Hancock, J.R.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
Packed capillary column liquid chromatography (LC) - electrospray mass spectrometry (ESI-MS) and tandem mass spectrometry (MS/MS were used to identify munitions grade mustard hydrolysis products, including five longer chain diols, two partial hydrolysis products and three either/thioether macrocycles. All ESI-MS data were collected under collisionally activated dissociation (CAD) conditions optimized to facilitate acquisition of both molecular and product ion information that could be used for structural identification purposes. Interpretation of the ESI-MS data enabled characterization of the diols resulting from hydrolysis of all three principal sulfur vesicants, bis(2-chloroethyl)sulfide (mustard or H), bis(2-chloroethylthio)ethane (sesquimustard or Q) and bis(2-chloroethylthio)ethyl) ether (T), as well as novel products not previously associated with sulfur vesicant hydrolysis. The reported ESI-MS data could prove valuable for the identification of thiodiglycol and other sulfur vesicant hydrolysis products in samples collected by the Canadian Forces, during base cleanup operations or in support of United Nations Chemical Weapons Convention inspections.
Keywords
Thiodiglycol;Electrospray mass spectrometry;CW identification
Report Number
DRES-691 —
Date of publication
01 Jan 1998
Number of Pages
22
DSTKIM No
98-00455
CANDIS No
507090
Format(s):
Hardcopy;Document Image stored on Optical Disk

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