ESTIMATION OF HUMAN TOXICITY FROM ANIMAL INHALATION TOXICITY DATA: 1. MINUTE VOLUME-BODY WEIGHT RELATIONSHIPS BETWEEN ANIMALS AND MAN

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Authors
  1. Bide, R.W.
  2. Armour, S.J.
  3. Yee, E.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
The relationship between body weight (BW) and respiratory minute volume (Vm) was reviewed by collecting a data base from the literture of minute volume rates that encompassed species from mice at 12 g body weight to horses and a giraffe at approximately equals to 500 kg body weight. The data were separated into anesthetized and non-anesthetized groups and juvenile animals were removed from the non-anesthetized group. The final data set of non-anesthetized animals contained 134 studies representing 2304 animals and 18 species. The data show a power-law (allometric) relationship between the minute volume and body weight. The scaling or allometric parameters in this power-law have been estimated suing a linear regression of the logarithms of the minute volume against body weight. The resulting allometric equations were; Log 10 Vm = -0.286 + 0.802 Log 10 BW or Vm = 0.518 BW 0.802. From these equations a corresponding set of minute volumes were obtained for various body weights of humans eg. 15.6 L/min for a 70 kg human. The results of the analyses were compared to similar studies in the literature. The relationship is recommended for military uses because it is derived from non-anesthetized, young adult mammals which are expected to mimic the soldier.
Keywords
Inhalation
Report Number
DRES-673 —
Date of publication
01 Oct 1997
Number of Pages
46
DSTKIM No
98-00359
CANDIS No
507151
Format(s):
Hardcopy;Document Image stored on Optical Disk

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