MODAFINIL DURING 64 HR OF SLEEP DEPRIVATION: DOSE-RELATED EFFECTS ON FATIGUE, ALERTNESS, AND COGNITIVE PERFORMANCE

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Authors
  1. Baranski, J.V.
  2. Cian, C.
  3. Esquivie, D.
  4. Pigeau, R.A.
  5. Raphel, C.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
Modafinil is a relatively new syntehtic psychostimulant that has been shown to promote vigilance and arousal with apparently few physiological side effects. Accordingly, modafinil may provide a safe and effective alternative to the more commonly used amphetaminic lass of stimulants, for example, in clinical settings to treat sleep disorders (e.g., idiopathic hypersomina and narcolepsy) and sustained military operations to promote vigilance during periods of prolonged sleep deprivation. In this article, we investigate the relative effects of three doses of modafinil on fatigue and cognitive performance in a double-blind, placebo-controlled, 64-hr sleep-deprivation study. We observe a dose-related ordering on subjective measures of fatigue, motivation, subjective performance, and alertness following 4 min with eyes closed and on objective measures of serial reaction time, complex mental addition, and short-term memory. Specifically, 300 mg of modafinil in a 24-hr period (100 mg every 8 hr) was found to maintain cognitive performance at or near baseline levels throughout the sleep-deprivation period, 150 mg of modafinil in a 24-hr period (50 mg every 8 hr) provided some maintenance of performance, and 50 mg of modafinil in a 24-hr period (16.7 mg every 8 hr) was not substantively different from placebo. TRUNCATED
Keywords
Modafinil;Sustained operations;Stimulants
Report Number
DCIEM-96-P-45 — Paper
Date of publication
01 Mar 1996
Number of Pages
24
DSTKIM No
98-01972
CANDIS No
508799
Format(s):
Hardcopy;Document Image stored on Optical Disk

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