PHYSICAL EXERCISE AS A HUMAN MODEL OF LIMITED INFLAMMATORY RESPONSE

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Authors
  1. Shek, P.N.
  2. Shephard, R.J.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
One of the most common complications of military trauma is an exaggerated and uncontrolled inflammatory response, which may lead to multiple organ failure, the primary cause of morbidity and mortality in combat casualties with severe wounds. An inflammatory response is commonly seen under the pathological conditions of trauma, sepsis and burns. It is becoming increasingly evident that most, if not all of the distinguishing features of a classical inflammatory response are detectable in an exercising individual, namely mobilization and activation of granulocytes, lymphocytes, and monocytes; release of inflammatory factors and soluble mediators; involvement of active phase reactants; and activation of the complement and other reactive humoral cascade systems. While the manifestation of many exercise-induced immune and related changes has been reported and confirmed repeatedly, the underlying mechanisms triggering and modulating the elicited immune responses are at best, poorly understood. Unlike the exaggerated and sometimes uncontrollable inflammatory response in septic and trauma patients resulting in morbidity and mortality, strenuous and severe exercise normally elicits an inflammatory response of a subclinical nature to facilitate the repairing process for site-specific tissue damage. TRUNCATED
Keywords
Cytokines;Inflammatory response;Site-specific tissue damage;Immune response;Sepsis;Burns;Infections
Report Number
DCIEM-97-P-37 — Reprint
Date of publication
01 Aug 1997
Number of Pages
11
Reprinted from
Can J Physiol, Pharmacol, vol 76, 1998, p 589-597
DSTKIM No
99-00192
CANDIS No
510018
Format(s):
Hardcopy;Document Image stored on Optical Disk

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