ANALYSIS OF GA, GB, GD AND GF IN AQUEOUS SAMPLES BY PACKED CAPILLARY LC-ESI-MS

PDF

Authors
  1. D'Agostino, P.A.
  2. Hancock, J.R.
  3. Provost, L.R.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
Packed capillary column liquid chromatography (LC) - electrospray mass spectrometry (ESI-MS) was used for the first time to detect and identify four common organophosphorus chemical warfare agents in aqueous samples. Aqueous samples containing the organophosphorus chemical warfare agents in the 0.01 to 0.1 mg/mL range were analysed directly by packed capillary LC-ESI-MS with the chemical warfare agents and several minor related impurities being well resolved under acetonitrile/water gradient elution conditions. The ESI-MS data for isopropyl methylphosphonofluoridate (GB or sarin), ethyl dimethylphosphoramidocyanidate (GA or tabun), cyclohexyl methylphosphonofluoridate (GF) and pinacolyl methylphosphonofluoridate (GD or soman) were acquired with a sampling cone voltage setting that promoted collisionally activated dissociation, and resulted in the acquisition of informative mass spectra containing both molecular and product ion information. The developed method appears to be an attractive alternative to GC-MS for the analysis of aqueous samples containing organophosphorus chemical warfare agents and their hydrolysis products, since they may be analysed directly without the need for additional sample handling.
Keywords
Electrospray mass spectrometry;Electrospray;CW identification;GC/MS;LC/ESI/MS;Chemical identification;Electrospray mass spectroscopy
Report Number
DRES-TM-1999-047 — Technical Memorandum
Date of publication
01 Feb 1999
Number of Pages
21
DSTKIM No
99-00858
CANDIS No
510808
Format(s):
Hardcopy;Document Image stored on Optical Disk

Permanent link

Document 1 of 1

Date modified: