In Vivo Indomethacin Treatment Inhibits Prostaglandin E2 and Reverses the Post-Exercise Suppression of Natural Killer Cell Activity

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Authors
  1. Rhind, S.G.
  2. Gannon, G.A.
  3. Masatoshi, S.
  4. Shepard, R.J.
  5. Shek, P.N.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
[Title of article in journal: "Indomethacin treatment inhibits circulating PGE2 and reverses postexercise suppression of natural killer cell activity."] Natural killer (NK) cells are important in combating viral infections and cancer. NK cytolytic activity (NKCA) is often depressed during recovery from strenuous exercise. Lymphocyte subset redistribution and/or inhibition of NK cells via soluble mediators, such as prostaglandin (PG) E2 and cortisol, are suggested as mechanisms. Ten untrained (peak O2 consumption = 4.40 + or - 3.5 ml-kg 1(-).min 1(-)) men completed at 2-wk intervals a resting control session and three randomized double-blind exercise trials after the oral administration of a placebo, the PG inhibitor indomethacin (75 mg/day for 5 days), or naltrexone (reported elsewhere). Curculating CD3-CD16+/56+ NK cell counts, PGE2, cortisol, and NKCA were measured before, at 0.5-h intervals during, and at 2 and 24 h bout of cycle ergometer exericse (65% peak O2 consumption). During placebo and indomethacin conditions, exercise induced significant (P<0.0001) elevations of NKCA (>100%) and circulating NK cell counts (<350%) compared with corresponding control values. TRUNCATED
Keywords
Immune suppression;Immune system;Natural killer cells;Natural immunity
Report Number
DCIEM-98-P-30 — Reprint
Date of publication
01 Apr 1999
Number of Pages
13
Reprinted from
American Physiological Society, 1999, p R1496-R1505
DSTKIM No
99-01002
CANDIS No
510914
Format(s):
Hardcopy;Document Image stored on Optical Disk

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