In Vivo Indomethacin Treatment Inhibits Prostaglandin E2 and Reverses the Post-Exercise Suppression of Natural Killer Cell Activity


  1. Rhind, S.G.
  2. Gannon, G.A.
  3. Masatoshi, S.
  4. Shepard, R.J.
  5. Shek, P.N.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
[Title of article in journal: "Indomethacin treatment inhibits circulating PGE2 and reverses postexercise suppression of natural killer cell activity."] Natural killer (NK) cells are important in combating viral infections and cancer. NK cytolytic activity (NKCA) is often depressed during recovery from strenuous exercise. Lymphocyte subset redistribution and/or inhibition of NK cells via soluble mediators, such as prostaglandin (PG) E2 and cortisol, are suggested as mechanisms. Ten untrained (peak O2 consumption = 4.40 + or - 3.5 ml-kg 1(-).min 1(-)) men completed at 2-wk intervals a resting control session and three randomized double-blind exercise trials after the oral administration of a placebo, the PG inhibitor indomethacin (75 mg/day for 5 days), or naltrexone (reported elsewhere). Curculating CD3-CD16+/56+ NK cell counts, PGE2, cortisol, and NKCA were measured before, at 0.5-h intervals during, and at 2 and 24 h bout of cycle ergometer exericse (65% peak O2 consumption). During placebo and indomethacin conditions, exercise induced significant (P<0.0001) elevations of NKCA (>100%) and circulating NK cell counts (<350%) compared with corresponding control values. TRUNCATED
Immune suppression;Immune system;Natural killer cells;Natural immunity
Report Number
DCIEM-98-P-30 — Reprint
Date of publication
01 Apr 1999
Number of Pages
Reprinted from
American Physiological Society, 1999, p R1496-R1505
Hardcopy;Document Image stored on Optical Disk

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