Caffeine, Ephedrine and their Combination: Effects on Blood Pressure and Heart Rate


  1. Bordeleau, R.
  2. Bell, D.G.
  3. Jacobs, I.
  4. Zamecnik, J.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
The ability to maintain or enhance our soldiers' performance could be crucial to a mission in scenarios such as extended search and rescue and sustained operation. In this regard, DCIEM has been investigating the effects of ingesting various substances to determine their effect on physical performance. Two such substances, caffeine (c) and ephedrine (e) ingested in combination have been shown to enhance physical performance. Before these substances can be used by Canadian Forces personnel it is imperative that no long lasting adverse effects result as a consequence of their ingestion. Therefore, it was the purpose of this paper to look at the effects of an acute ingestion of caffeine, ephedrine and their combination on heart rate and blood pressure variables over an extended period. The results indicated that in non-users of caffeine systolic blood pressure (SBP) passed hypertensive levels (140 mm Hg) and remained at this level for 3 hours after ingesting the combination treatment. SBP levels returned to placebo levels after 8 hours. Although diastolic blood pressure and HR also increased after treatment ingestion, their effects were minimal and dissipated by 24 hours. It appears that in a normo-tensive healthy young individual acute ingestion of a preparation of caffeine, ephedrine or the two in combination would not have long lasting adverse effect on BP and HR.
Ergogenic aids;Physical training;Ergogenic effects;Health risk;Diastolic;Systolic
Report Number
DCIEM-TR-1999-069 — Technical Report
Date of publication
01 Aug 1999
Number of Pages
Hardcopy;Document Image stored on Optical Disk

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