Characterization and Assessment of Virulence Factors and Antigenic Determinants of Pseudomonas (Burkholderia) Pseudomallei

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Authors
  1. Woods, D.E.
  2. Cherwonogrodzky, J.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN);Calgary Univ, Calgary ALTA (CAN) Dept of Microbiology and Infectious Diseases
Abstract
Burkholderia pseudomallei, the etiologic agent of melioidosis, is responsible for a broad spectrum of infections observed in both humans and animals (13, 52). Clinical manifestations of melioidosis may range from the chronic, sub-clinical forms to the acute septicemic and acute pulmonary presentations of the disease. In many instances the acute manifestations of melioidosis are associated with an appalling mortality rate, even when vigorous chemotheraputic intervention is implemented (38, 73). To this end, a prophylaxis measure in the form of a vaccination against B. pseudomallei infections would be desirable for those who reside in endemic regions or other populations that may be at particular risk of acquiring the disease. Unfortunately, however, there are currently no suitable vaccine preparations available for this undertaking. The primary reason for the lack of a vaccination against melioidosis is that to date very little is understood regarding the pathogenic mechanisms associated with this organism. Although a number of putative virulence determinants have been identified, including secreted and cell-associated antigens, they are poorly characterized at both the immunological and biochemical levels (11, 26, 33, 34, 70, 76, 87, 88). TRUNCATED
Keywords
Antibacterial drugs;Pseudomonas mallei;Pseudomonas pseudomallei;Gene sequences;Cloning
Report Number
DRES-CR-1999-140 — Contract Report
Date of publication
01 Nov 1999
Number of Pages
96
DSTKIM No
CA000314
CANDIS No
512200
Format(s):
Hardcopy;Document Image stored on Optical Disk

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