Reducing the Dose of Combined Caffeine and Ephedrine Preserves the Ergogenic Effect

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Authors
  1. Bell, D.G.
  2. Jacobs, I.
  3. McLellan, T.M.
  4. Zamecnik, J.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
Ingestion of a combination of 5 mg - kg 1(-) caffeine (C), and 1 mg - kg 1(-) ephedrine (E) was reported to have an ergogenic effect on high intentiy aerobic exercise performance, but 25% of the subjects experienced vomiting and nausea while engaging in hard exercise after the treatment. The present study was undertaken to investigate whether reduced levels of C+E would alleviate the problem and maintain the ergogenic effect. Twelve healthy untrained male subjects completed four randomized and double-blind, cycle ergometer trials to exhaustion at a power output equivalent to -85% VO2peak 1.5-2 hours after ingesting a placebo (P) or a mixture of C+E in the following doses: 5 mg - kg 1(-) of C plus 0.8 mg - kg 1(-) of E (CLE); 4 mg - kg 1(-) of C plus 1 mg - kg 1(-) of E (LCE); or 4 mg - kg 1(-) of C plus 0.8 mg - kg 1(-) of E (LCE). Trials were separated by 1 wk. Venous blood samples were obtained and anlyized for caffeine and ephedrine levels 1.5 h post-drug ingestion. TRUNCATED
Keywords
Ergogenic aids;Physical training;Ergogenic effects;Human performance
Report Number
DCIEM-SL-1999-061 — Scientific Literature
Date of publication
01 Mar 2000
Number of Pages
7
Reprinted from
Aviation, Space, and Environmental Medicine, vol 71, no 4, 2000, p 415-419
DSTKIM No
CA001744
CANDIS No
513548
Format(s):
Hardcopy;Document Image stored on Optical Disk

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