Allometric respiration/body mass data for animals to be used for estimates of inhalation toxicity to young adult humans

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Authors
  1. Bide, R.W.
  2. Armour, S.J.
  3. Yee, E.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
The relationship between body weight (BW) and respiratory minute volume (Vm) was reviewed by collecting a database from the literature. The data were separated into anaesthetized and non-anaesthetized groups. Only young adult terrestrial mammals were included in the final data set. This database is the largest to be reported to date, is the first to separate the anaesthetized and non-anaesthetized groups and is matched to the target population of young, fit adult humans. The data set of non-anaesthetized animals contained 142 studies representing 2616 animals and 18 species from mice at 12 g body weight to horses and a giraffe at ca. 500 kg body weight. Analysis of the data indicated a power law (allometric) relationship between the minute volume and body weight are: log10 Vm = -0.302 + 0.809 log10BW and Vm = 0.499 BW/0.809, where Vm is the minute volume (1 min 1(-)) and BW is the body weight (kg). From these equations, a minute volume of 15.5 1 min 1(-) was obtained for a 70 kg human in the same physiological and/or emotional state as the animals. The results of the analyses were compared to other empirical studies in the literature, the more recent of which also indicated a scaling factor of 0.8. TRUNCATED
Keywords
Body mass;Allometric respiration;Inhalation toxicity;Human estimates;Inhalation
Report Number
DRES-OL-1999-010 — Reprint
Date of publication
01 May 2000
Number of Pages
19
Reprinted from
J. Appl. Toxicol, vol 20, 2000, p 273-290
DSTKIM No
CA010719
CANDIS No
514130
Format(s):
Hardcopy;Document Image stored on Optical Disk

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