Determination of organophosphorus chemical warfare agents and their hydrolysis products in soil by packed capillary liquid chromatography - electrospray mass spectrometry (LC-ESI-MS)

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Authors
  1. D'Agostino, P.A.
  2. Hancock, J.R.
  3. Provost, L.R.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
An analytical method based on aqueous ultrasonic extraction and packed capillary LC-ESI-MS analysis was developed and compared to the existing GC-MS based method for the trace determination of organophosphorus chemical warfare agents and their hydrolysis products in contaminated soil. Three soils, a red clay, a tan sandy loam and a brown sandy clay loam, were selected and spiked with sarin and soman and their hydrolysis products, isopropyl methylphosphonic acid and pinacolyl methylphosphonic acid, at the 10 mu g/g level to assess recovery efficiency. Recovery of sarin and soman from the aqueous soil extracts was comparable to the existing analytical method, with a significant improvement in recovery being demonstrated for the chemical warfare agent hydrolysis products. Sarin and soman were recovered in the 20% to 90% range from the three soil types with aqueous extraction, while the hyrolysis products of these chemical warfare agents were extracted almost quantitatively, with recoveries in excess of 80% for all three soil types. The developed soil extraction and analysis method appears to be an attractive alternative to the GC-MS based method, since aqueous extracts containing chemical warfare agent hydrolysis products may be analysed directly, eliminating the need for additional sample handling and derivatization steps.
Keywords
Sarin;Soman;LC/ESI/MS;Electrospray mass spectrometry;Packed capillary column liquid chromatography
Report Number
DRES-TR-2000-075 — Technical Report
Date of publication
01 Jun 2000
Number of Pages
35
DSTKIM No
CA010008
CANDIS No
514140
Format(s):
Hardcopy;Document Image stored on Optical Disk

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