Adhesion molecule expression in acute and chronic exercise

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Authors
  1. Shephard, R.J.
  2. Gannon, G.
  3. Hay, J.B.
  4. Shek, P.N.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
Adhesion molecules expressed on leukocytes and the vascular endothelial lining include the selectins, integrins, members of the immunoglobulin superfamily, and mucins. The changes in their expression that develop with acute and chronic exercise are briefly reviewed. Adhesion molecules are thought to modulate leukocyte trafficking, accounting for changes in the counts and possibly also the functional activity of various leukocyte subsets during and following an acute bout of physical activity. Some of the changes in the surface density of adhesion molecules can be explained through the action of epinephrine and other humoral factors on their expression, but an influence of sympathetic nerve terminals on cells sequestered in the spleen and liver, and an influx into the general circulation of leukocytes of differing phenotype also appear to be involved.
Keywords
Immunostimulating;Epinephrine;Exertion;Interleukin-1beta;Leukocytes;Immunoglobin;Selectins;Integrins;Mucins;Cell trafficking;Lymphocyte trafficking;CAM (Cellular Adhesion Molecules)
Report Number
DCIEM-SL-1999-110 — Paper
Date of publication
01 Sep 2000
Number of Pages
24
DSTKIM No
CA010049
CANDIS No
514212
Format(s):
Hardcopy;Document Image stored on Optical Disk

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