Capillary electrophoresis in detection of chemicals related to the chemical weapons convention


  1. Boulet, C.A.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
This article describes the applications of capillary electrophoresis (CE) to the analysis of compounds relevant to the Chemical Weapons Convention (CWC). CE is an analytical technique that employs narrow-bore, fused-silica capillaries to perform high-efficiency separations of analytes based on their mobilities in an electric field. In CE, analytes are dissolved in a buffer solution and placed in a capillary to which an electric field is applied. The analytes then migrate at a rate determined by their charge and size and are detected as they migrate past a detector. CE can analyze a broad range of compounds and is particularly applicable to the analysis of water-soluble degradation products of scheduled compounds under the CWC. Compounds typically analyzed by CE include the hydrolysis products of nerve agents such as the alklphosphonates and hydrolytic or oxidative products of the sulfur-mustards such as thiodiglycol. The alkyphosphonates require the use of indirect ultraviolet (UV) detection or other detection methods as they do not possess a suitable UV chromophore. Degradation products of the sulfur mustards have been analyzed by micellar electrokinetic chromatography (MEKC) and direct UV detection. TRUNCATED
Capillary electrophoresis (CE);MEKC (Micellar electrokinetic chromatography)
Report Number
DRES-SL-1999-040 — Paper
Date of publication
08 Nov 2000
Number of Pages
Hardcopy;Document Image stored on Optical Disk

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