Malaria: Basic biology and options for therapy and prophylaxis

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Authors
  1. Berger, B.J.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
Malaria remains one of the world's greatest health threats with 200 - 300 million infections and 2 - 3 million deaths per year. Increasingly, peace-keeping deployments occur in regions of the world with high incidence rates of malaria, and in areas where resistance to commonly used antimalarials is frequent. This review covers the basic biological properties of malaria parasites and provides information on the biochemistry and pharmacology of the currently available antimalarial therapies. The current status on drug resistance in malaria is also presented.
Keywords
Quinine;Chloroquine;Mefloquine;Pronguanil;Pyrimethamine/sulfadoxine;Tetracycline/doxycycline;Halofantrine;Artemether;Artesunate;Quinidine;Pyronaridine;Atovaquone;Drug resistance
Report Number
DRES-TM-2000-055 — Technical Memorandum
Date of publication
01 Sep 2000
Number of Pages
88
DSTKIM No
CA010472
CANDIS No
515010
Format(s):
Hardcopy;Document Image stored on Optical Disk

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