Characterization of 3 strains of Yersinia pestis

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Authors
  1. Kournikakis, B.
  2. Bateman, C.
  3. Cherwonogrodzky, J.W.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
We have characterized 3 strains of Yersinia pestis currently held in the culture collection at DRES by colonial morphology, antibiotic sensitivity and Biolog (TRADEMARK) metabolic identification profiles. On agar medium, colonies were round and waxy, resembling other Gram-negative cells such as Escherichia coli. Cultures grew better on Yersinia selective media than on trypticase soy agar or nutrient agar. Antibiotic sensitivities showed that the 3 strains were sensitive to aminoglycosides, the cephalosporins/cephams, most of the beta lactams/penicillins (e.g. clindamycin), macrolides (e.g. erthromycin, colisitin, rifampin and vancomycin) polymyxin B, sulfonamide (e.g. sulfisoxazole) and Yesinia pestis strain GB was resistant to doxycycline. This study is part of a larger effort to characterize all the Risk Group 3 bacterial agents used in the research program at DRES. Although DRES does not currently have a mandate to carry out rapid BW agent identification, this and similar studies could help form the basis on which to build such a capability. The conept of a Defence Research Center for Infectious Agents (DRCIA) is discussed.
Keywords
Yersinis pestis;Y.pestis;Biolog
Report Number
DRES-TM-2000-164 — Technical Report
Date of publication
01 Dec 2000
Number of Pages
28
DSTKIM No
CA010576
CANDIS No
515365
Format(s):
Hardcopy;Document Image stored on Optical Disk

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