Sepsis and inflammatory response mechanisms: An activity stress model in humans


  1. Shephard, R.J.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN);Toronto Univ, Toronto ONT (CAN) Faculty of Physical Education and Health;Toronto Univ, Toronto ONT (CAN) Dept of Public Health and Science
Military operations and training programs may be very rigorous, involving not only prolonged periods of heavy physical activity, but also exposure to extreme environments, such as hot or cold temperatures. The effects of such challenges on a soldier's health are complex, in part becasue of interactions between the various stressors. It is known that military personnel participating in lengthy and phsuically challenging operations and training are predisposed to a decrement in immune function and an increased susceptibility to infectious disease. From an occoupational health perspective, immune suppression could impair both physical and mental performance. This study examined interactionsof the exercise-induced immunomodulation with various forms of environmental stress, explores mechanisms, and examines implications for the overall health of military personnel. The experimental design was targeted at elucidating the basic process of exercise-triggered inflammation, including issues of lymphocyte recirculation and activation. It further examined the immune disturbances induced by acute and chronic exercise. Possible exacerbation of exercise-induced changes by adverse environments, particularly heat and cold exposure was also investigated. TRUNCATED
Sepsis;Cytokines;Infections;Inflammatory response;Immune response;Bacterial infections;Animal model;Post surgery infections;Cytotoxicity;Physical activity
Report Number
DCIEM-CR-2001-017 — Contractor Report
Date of publication
13 Jan 2001
Number of Pages
Hardcopy;Document Image stored on Optical Disk

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