Hormones in human African trypanosomiasis

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Authors
  1. Radomski, M.W.
  2. Brandenberger, G.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
Humans suffering from African trypanosomiasis or sleeping sickness demonstrate major disruptions in their circadian sleep-wake distribution, with the intensity of the sleep-wake disturbances increasing with the stage of advancement of the disease. Buguet et al. postulated that the disruptions in the circadian sleep-wake cycle in infected humans at the stage of meningoencephalitis may be due to a disease-induced disturbance of the circadian timing system. We undertook a series of hormonal studies on African patients with varying degrees of severity of infection to assess whether the disruptions in the circadian sleep-wake cycle extended to hormones with well-known circadian rhythms in healthy humans. Several hormones exhibit circadian rhyths which may be controlled by a circadian tiing system synchronized to the sleep-wake cycle, or are dependent upon both of these influences. TRUNCATED
Keywords
Sleeping sickness;Human African Trypanosomiasis (HAT)
Report Number
DCIEM-98-P-64 — Paper
Date of publication
15 Mar 2001
Number of Pages
14
DSTKIM No
CA010593
CANDIS No
515447
Format(s):
Hardcopy;Document Image stored on Optical Disk

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