Inhalation toxicologic procedures for exposure of small laboratory animals to highly toxic materials: Part B: Exposures to aerosols with notes on toxicity of Ricin

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Authors
  1. Bide, R.W.
  2. Risk, D.J.
  3. Ladouceur, M.F.
  4. Beifus, D.G.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
The estimation of military hazard from toxic materials usually requires an estimate of the human toxicity. With expensive, rare and highly toxic substances, only small amounts of substance may be available for testing or safety considerations may restrict the amounts of material that may be used at one time. A functional modular system has been developed for the exposure of mice, rats and guinea pigs to highly toxic liquid, gas or aerosol test materials that requires a minimum of trial material. The total system is described in this aerosol centred report and in companion reports which describe methods for use with gasses. The aerosol exposure system is operated dynamically in a chamber with a very small volume. Provision is made to continuously monitor the concentration and composition of the aerosol in the test atmospheres and grab sambles are taken to establish the exposure concentrations. Respiration of the subjects may be continuously monitored during the exposures but because of the restraint of the animals required by the nose only configuration, observations of behaviour during the exposures are not possible. The development and validation fo this configuration are described and toxicity studies with Ricin are used as examples. TRUNCATED
Keywords
Ricin;Inhalation toxicity;Inhalation;Human estimates
Report Number
DRES-TM-2001-066 — Technical Memorandum
Date of publication
01 Feb 2001
Number of Pages
44
DSTKIM No
CA010964
CANDIS No
515632
Format(s):
Hardcopy;Document Image stored on Optical Disk

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