Melatonin and zopiclone as pharmacologic aids to facilitate crew rest


  1. Paul, M.A.
  2. Brown, G.
  3. Buguet, A.
  4. Gray, G.
  5. Pigeau, R.A.
  6. and others
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
In response to mission imperatives, transport aircrews must often sleep at inappropriate circadian times resulting in inadequate sleep. This study was undertaken to determine whether either melatonin or zopiclone could facilitate early circadian sleep, and to assess whether either of these mediciations would result in a psychomotor performance decrement which would preclude their use in aircrew. Thirteen subjects from DCIEM completed a double-blind cross-over protocol. All subjects were assessed for psychomotor performance during 3 drug conditions (placebo, 10 mg melatonin, and 7.5 mg zopiclone), which were separated by one week. Each of these conditions involved 2 nights of sleep, back-to-back, with the first night being a normal circadian control sleep (23:00) h bedtime, arising at 06:45 h), and the second night being an early circadian drug sleep (drugs at 16:45 h, 17:00 h edtime, arising at 23:45 h). All subjects were tested for psychomotor performance, on both nights of each of the 3 drug conditions, pre- and post-sleep. TRUNCATED
Sleep problems;Crew rest
Report Number
DCIEM-SL-2000-053 — Scientific Literature
Date of publication
01 Nov 2001
Number of Pages
Reprinted from
Aviation, Space, and Environmental Medicine, vol 72, no 11, 2001, p 974-984
Hardcopy;Document Image stored on Optical Disk

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