Effects of modafinil on cognitive performance during 40 hr of sleep deprivation in a warm environment


  1. Baranski, J.V.
  2. Gil, V.
  3. McLellan, T.M.
  4. Moroz, D.
  5. Buguet, A.
  6. Radomski, M.W.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN);Centre de Recherches du Service de Sante des Armees, La Tronche (France)
This study examined the effect of the psychostimulant modafinil on cognitive performance during 40 hr of sleep deprivation in a warm environment. Five men were randomly assigned to a modafinil (3 x 100 mg/24 hr) and a placebo trial on consecutive weeks, with a 5-day intervening "wash-out" period. Each trial involved a thermoneutral control day (outside of the climatic chamber) followed by a 40-hr sleep deprivation period in a climatic chamber at 30C with 50% relative humidity. Ten cognitive testing sessions were conducted on each trial; each session lasted approximately 45 min, and they occurred at 6-hr intervals. The task battery included subjective assessments of mood, fatigue, and motivation and cognitive assessments of serial reaction time, logical reasoning (logical reasoning task [LRT]), visual comparison (CMP), mental addition (ADD), vigilance (detection of repeated numbers [DRN]), and multitasking. In addition, for 4 of the cognitive tasks that permitted a quantitative index of response accuracy (i.e., LRT, CMP, DRN, and ADD), participants provided estimates of their performance before and after each session to permit an evaluation of the extent to which they could accurately self-monitor their own cognitive abilities. TRUNCATED
Modafinil;Sustained operations;Continuous operations (CONOPS) Stimulants;Sustained operations (SUSOPS)
Report Number
DCIEM-SL-2000-117 — Scientific Literature
Date of publication
01 Nov 2000
Number of Pages
Hardcopy;Document Image stored on Optical Disk

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