Effect of Ingesting Caffeine and Ephedrine on 10-km Run Performance


  1. Bell, D.G.
  2. McLellan, T.M.
  3. Sabiston, C.M.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
The ingestion of either caffeine (C) or ephedrine (E) has been shown to improve performance during high-intensity aerobic activity lasting 10-20 min, with an additive effect being found when the combination (C+E) was ingested. It was the purpose of this study to determine if the addition of E to C would improve performance in activity lasting longer than 20 min. One and one half hours after ingesting a placebo (P), (4mg/kg), E (0.8mg/kg), or C + E, 12 subjects performed a 10-km run while wearing a helmet and backpack weighing 11 kg. The trials were performed in a climatic suite at 12-13C, on a treadmill where the speed was regulated by the subject. VO2, VCO2, VE, heart rate (HR), and rating of perceived exertion (RPE) were measured during the run at 15 and 30 min, and again when the individual reached 9 km. Blood was sampled at 15 and 30 min and again at the end of the run and assayed for lactate, glucose, and catecholamines. Run times (mean + or - SD), in minutes, were for C (46.0 + or - 2.8), E (45.5 + or - 2.9), C + E (45.7 + or - 3.3), and P (46.8 + or - 3.2). The run times for the E trials (E and C + E) were significantly reduced compared with the non-E trials (C and P). Pace was increased for the E trials compared with the non-E trials over the last 5 km of the run. TRUNCATED
Ephedrine;Ergogenic aids;Performance enhancing;Sympathomimetic agents
Report Number
DCIEM-SL-2000-087 — Scientific Literature
Date of publication
17 Jun 2002
Number of Pages
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