Paralysis in Nerve Agent Toxicosis in Guinea Pigs

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Authors
  1. Bide, R.W.
  2. Schofield, L.
  3. Risk, D.J.
Corporate Authors
Defence R&D Canada - Suffield, Ralston ALTA (CAN)
Abstract
Since the discovery of the G-type nerve agents, there have been numerous studies of Central Nervous System (CNS) involvement in the etiology of organophosphate poisoning, notably associated with status elipticus and/or "electrographic seizures". Brain damage from these effects has been demonstrated as "neuronal necrosis" primarily in the cortex, thalamus and hippocampus. However, despite recurring references to CNS damage, to the author's knowledge there have been no reports of long term paralysis mainfested within 24 hr of nerve agent exposure. Occasional paralysis following an asymptomatic time interval of 7-14 days has been reported. This report is intended to summarize the immediate, nerve agent induced paralytic events recorded in guinea pigs (as incidental observations) during development of the Canadian Reactive Skin Decontaminant Lotion (RSDL®). Because the experiments were designed to assess the decontamination procedures, there were no apparent relationships between the amounts of agent applied and the sequellae recorded. In the experiments described, massive cutaneous doses of agent were applied to large numbers of guinea pigs (GD to 1277; VX to 108) followed by decontamination with the RSDL® or predecessor lotions and solvents.

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Keywords
RSDL (Reactive Skin Decontaminant Lotion);MPEG
Report Number
DRDC-SUFFIELD-TR-2002-067 — Technical Report
Date of publication
01 Sep 2002
Number of Pages
32
DSTKIM No
CA021650
CANDIS No
518363
Format(s):
Hardcopy;Document Image stored on Optical Disk

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