The Impact of Sertraline on Psychomotor Performance

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Authors
  1. Paul, M.A.
  2. Gray, G.
  3. Lange, M.
Corporate Authors
Defence R&D Canada - Toronto, Toronto ONT (CAN)
Abstract
Aircrew receiving treatment for depression are grounded during treatment and follow-up observation, generally amounting to at least 1 yr. Selective serotonin re-uptake inhibitors (SSRIs) offer new treatment options for depression, of which sertraline (Zoloft™) has the least imposing side-effect profile. There has been considerable interest in the possibility of returning aircrew to restricted flying duties once stablized to determine whether or not sertraline effects psychomotor peformance. There were 19 volunteer non-depressed subjects (12 men and 7 women) who were assessed for psychomotor performance during placebo and sertraline treatment, in a double-blind cross-over protocol in counter balanced order. Each treatment arm lasted 5 wk and involved ingesting one capsule each morning. TRUNCATED
Keywords
Aircrew;Antidepressants;Psychomotor performance;Side effects
Report Number
DRDC-TORONTO-SL-2001-052 — Scientific Literature
Date of publication
01 Oct 2002
Number of Pages
8
Reprinted from
Aviation, Space and Environmental Medicine, vol 73, no 10, 2002, p 964-970
DSTKIM No
CA021743
CANDIS No
518479
Format(s):
Hardcopy

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