Effect of Modafinil on Core Temperature During Sustained Wakefulness and Exercise in a Warm Environment


  1. McLellan, T.M.
Corporate Authors
Defence R&D Canada - Toronto, Toronto ONT (CAN)
Previous studies have revealed that modafinil elevates resting core temperature during periods of sustained wakefulness. The purpose of this study was to examine the effects of modafinil on core temperature during rest and exercise throughout 40 h of sustained wakefulness in a warm environment. Ten males performed a drug session )three 100 mg doses per day) and a placebo session that involved a control day, 40 h of sustained wakefulness, and a recovery sleep. For 38 h of the sustained wakefulness, subjects were exposed to 30C with 50% relative humidity. During the afternoon of both days of wakefulness and during the early morning of the second day, subjects performed 2 h of exercise at 60% Vo2max while exposed to the warm environment. The data revealed that rectal temperature (Tre) was elevated at rest 0.15-0.2C following modafinil ingestion throughout the period of sustained wakefulness. This increase in body temperature at rest was due to an increase in heat production during the first day of wakefulness followed by a lower evaporative heat loss during the second day. During exercise, an inconsistent effect of the drug on Tre was observed throughout the 38-h period. On the first afternoon, the empact of modafinil on Tre was no longer evident after 20 min of exercise. TRUNCATED
Modafinil;Sustained operations;Sleep management;Stimulants;Core temperature
Report Number
DRDC-TORONTO-SL-2000-101 — Scientific Literature
Date of publication
01 Nov 2002
Number of Pages
Reprinted from
Aviation, Space, and Environmental Medicine, vol 73, no 11, 2002, p 1079-1088
Hardcopy;Document Image stored on Optical Disk

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