Sample Handling and Analysis Method for Chemical Warfare Agents in Soils Contaminated with Chemical and/or Biological Warfare Agents

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Authors
  1. D'Agostino, P.A.
  2. Chenier, C.L.
  3. Hancock, J.R.
Corporate Authors
Defence R&D Canada - Suffield, Ralston ALTA (CAN)
Abstract
A sample handling and analysis method was developed for the identification of chemical warfare agents (as intact compounds or as their hydrolysis products) in samples suspected to contain either chemical or biological warfare agent contamination. The method, based on aqueous extraction, autoclaving of the aqueous extract and LC-ESI-MS analysis was evaluated using three soil samples spiked at the 80 mu g/g level with triethyl phosphate, isopropyl methylphosphonic acid or thiodiglycol. All three compounds were readily extracted and identified following LC-ESI-MS, with triethyl phosphate undergoing some hydrolysis during the autoclaving procedure. This sample handling and analysis method for soil (or other) samples will form a cornerstone of the chemical/biological warfare agent identification strategy being developed at DRDC Suffield to meet National commitments.

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Keywords
Chemical warfare agents;Organophosphorus compounds;Sarin;G-agents;Liquid chromatography;Mass spectrometry;Electrospray;Electrospray mass spectrometry;LC/ESI/MS;Sarin;CW identification
Report Number
DRDC-SUFFIELD-TM-2003-025 — Technical Memorandum
Date of publication
01 Apr 2003
Number of Pages
26
DSTKIM No
CA022737
CANDIS No
519742
Format(s):
Hardcopy;Electronic Document(PDF)

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