Characterisation of Methionine Adenosyltransferase from Mycobacterium Smegmatis and M. Tuberculosis

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Authors
  1. Berger, B.J.
  2. Knodel, M.H.
Corporate Authors
Defence R&D Canada - Suffield, Ralston ALTA (CAN)
Abstract
Tuberculosis remains a serious world-wide health threat which requires the characterization of novel drug targets for the development of future antimycobacterials. One of the key obstacles in the definition of new targets is the large variety of metabolic alterations that occur between cells in the active growth and chronic/dormant phases of tuberculosis. The deal biochemical target should be active in both growth phases. Methionine adenosyltransferase, which catalyses the formation of S-adenosylmethionine from methionine and ATP, is involved in polymine biosynthesis during active growth and is also required for the methylation and cyclopropylation of mycolopids necessary for survival in the chronic phase.
Keywords
Tuberculosis;Mycobacterium tuberculosis;Mycobacterium smegmatis;Methionine adenosyltransferase;S-adenosylmethionine;Inhibition
Report Number
DRDC-SUFFIELD-SL-2003-050 — Reprint
Date of publication
16 Jun 2003
Number of Pages
14
Reprinted from
BMC Microbiology, vol 3,2003, p 1-13
DSTKIM No
CA022802
CANDIS No
519803
Format(s):
Hardcopy;Document Image stored on Optical Disk

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