Effects of Ephedrine, Caffeine, and Their Combination on Muscular Endurance


  1. Jacobs, I.
  2. Pasternak, H.
  3. Bell, D.G.
Corporate Authors
Defence R&D Canada - Toronto, Toronto ONT (CAN)
The purpose of this study was to investigate the effects of ingesting caffeine (C), ephedrine (E), and their combination on muscular endurance, using a double-blind, repeated measures design. Ninety minutes after ingesting either C(4 mg-kg1(-)), E (0.8 mg-kg1(-)), a combination of C+E, or a placebo (P), 13 male subjects performed a weight-training circuit consisting of three supersets (SS), each SS consisting of leg press (at 80% of 1 RM to exhaustion) followed by bench press (at 70% 1-RM to exhaustion); 2 min of rest intervened between SS. The trials involving ephedrine ingestion (C+E and E), when compared with the nonephedrine trials (C and P), cause significant increases (P<0.05) in the mean number of repetitions completed for both the leg-press and bench-press exercises but only during the first SS. During that first set, the mean number (+ or - SD) of repetitions for leg press was 19 + or - 8, 16 + or - 7, 14 + or - 6, and 13 + or - 5 for the C+E, E, C, and P trials, respectively. The mean numbers of repetitions for the first set of bench-press exercise were 14 = or - 3, 13 + or - 3, 12 + or - 3 for the C+E, E, C, and P trials, respectively. As a result, the total weight lifted during all three sets was greater for the trials involving ephedrine ingestion. Systolic blood pressure before exercise was significantly increased with both ephedrine treatment trials when compared with the other trials (C+E = 156 + or - 29 mm Hg; E = 150 + or - 14; C = 141 + or - 16; P = 138 + o
Endurance training;Ergogenic aids;Ergogenic effects;Human performance;Endurance training;Muscular strength;Resistance training
Report Number
DRDC-TORONTO-SL-2002-122 — Scientific Literature
Date of publication
01 Jan 2003
Number of Pages
Hardcopy;Document Image stored on Optical Disk

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