Liposomal Drug formulation

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Authors
  1. Wasserman, V.
Corporate Authors
Defence R&D Canada - Toronto, Toronto ONT (CAN);WASSERMAN (Veronica), Thornhill Ont (CAN)
Abstract
The ability of wound dressings to prevent undesired growth of microorganisms when applied to a wound surface is a critical factor in choosing a wound-care strategy. The bactericidal activity of the dressing will not only depend on the type and amount of drug loaded in the material but also on the form in which the drug was loaded. One objective of the current project was to investigate whether the bactericidal activity of the DRDC-Avitar dressing would be prolonged by loading the material with a liposome-encapsulated drug. Various liposomal formulations were tested and the pharmacokinetic profile of each formulation was evaluated. This study revealed that the antibacterial activity of liposomal drug-loaded dressings was prolonged, compared to that of free drug loaded material. However, more extensive studies are required to assess the feasibility of liposome utilisation in wound dressings.

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Keywords
mafenide acetate;HPLC;chlorhexidine;Wound dressings
Report Number
DRDC-TORONTO-CR-2003-092 — Contractor Report
Date of publication
01 Aug 2003
Number of Pages
43
DSTKIM No
CA023181
CANDIS No
520280
Format(s):
Electronic Document(PDF);CD ROM

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