Development and Evaluation of a Hydrogel Technology for its Potential as a Wound Dressing

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Authors
  1. Martineau, L.
  2. Shek, P.N.
Corporate Authors
Defence R&D Canada - Toronto, Toronto ONT (CAN)
Abstract
This report describes the development and in vivo testing of a proprietary hydrogel material technology developed under research contract for use as a wound dressing. Application of the liposomal hydrogel for 24 h provided a barrier that effectively prevented contamination of full-thickness wounds and burns in rats. Furthermore, application of liposomal ciprofloxacin-loaded hydrogel (Ciprogel) was also very effective both in limiting the progression of the infection to deeper tissues and, in treating an established wound infection in both rat and pig models of full-thickness wounds. While these studies indicated that Ciprogel was an effective drug delivery system, other experiments suggested that entrapment of ciprofloxacin in liposomes was neither required when large amounts of ciprofloxacin were loaded in the hydrogel nor did it provide a sustained-release bactericidal effect. A number of challenging technical issues for the development of the liposomal antibiotic hydrogel technology as a wound dressing were also identified during the product evaluation. In summary, taking into consideration the results from the assessment of the bactericidal properties of the hydrogel technology as well as the technical issues related to its development, the successful application of the liposomal antibiotic hydrogel material as a wound dressing for front-line military casualties remains to be developed.

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Keywords
Bactericidal;Ciprofloxacin;Hydrogels;Wound dressings
Report Number
DRDC-TORONTO-TR-2003-103 — Technical Report
Date of publication
10 Aug 2003
Number of Pages
67
DSTKIM No
CA023716
CANDIS No
521097
Format(s):
Electronic Document(PDF);CD ROM

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