Bi-layer Wound Dressing System for Combat Casualty Care

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Authors
  1. Martineau, L.
  2. Shek, P.N.
Corporate Authors
Defence R&D Canada - Toronto, Toronto ONT (CAN)
Abstract
Burn injuries remain a significant cause of morbidity and mortality during modern military conflicts and peacekeeping operations. Considering that commercially available dressings are not designed to meet the challenges of treating combat burn wounds, DRDC Toronto has designed a novel, absorbent and medicated bi-layer wound dressing to address key requirements for treating external war wounds. In the present report, we assessed our dressing’s bactericidal efficacy, wound healing properties, and skin-cooling characteristics using various pre-clinical models. Biopsies taken from full-thickness, pig wounds infected with Ps. aeruginosa and Staph. epidermidis showed a 2- to 5-log reduction in the bacterial load of antiseptic-treated wounds compared to those of control wounds. Though increasing the frequency of dressing changes led to a greater reduction in the wound bacterial load, the contamination levels of all antiseptic-treated wounds remained below 105 CFU/g of wound. Our results also show that 97% of partial-thickness, non-contaminated porcine wounds treated with the DRDC dressing healed within 7 days. In contrast, 92% of the wounds treated with commercial dressings healed within 9 days. Finally, the application of a moist DRDC dressing (to simulate a condition of exudate absorption; DRDCmoist) on a scald burn covering 25% of the dorsal area in rats reduced skin temperature (Tskin) by 1.7oC for 5 min, Tskin in DRDCmoist being comparable to that of control burned rats (BURN

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Keywords
skin cooling;bactericidal;wound healing
Report Number
DRDC-TORONTO-SL-2004-110;RTO-MP-HFM-109 — Scientific Literature
Date of publication
16 Aug 2004
Number of Pages
16
Reprinted from
Published in NATO RTO-MP-HFM-109 proceedings, August 2004, Pgs 34-1 to 34-16
DSTKIM No
CA025860
CANDIS No
523621
Format(s):
Electronic Document(PDF)

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