Immediate Post-Dosing Paralysis Following Severe Soman and VX Toxicosis in Guinea Pigs

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Authors
  1. Bide, R.W.
  2. Schofield, L.
  3. Risk, D.J.
Corporate Authors
Defence R&D Canada - Suffield, Ralston ALTA (CAN)
Abstract
There have been numerous studies of the central nervous system (CNS) involvement in organophosphate (OP) poisoning showing status epilepticus and/or ‘electrographic seizures’. Brain damage has been demonstrated as ‘neuronal necrosis’ primarily in the cortex, thalamus and hippocampus. To the authors’ knowledge there have been no reports of partial/total paralysis following close upon OP exposure although delayed paralysis has been reported. This report summarizes the immediate, OP induced paralytic events recorded in guinea pigs during development of the Canadian reactive skin decontaminant lotion (RSDL®).
Keywords
RSDL (Reactive Skin Decontaminant Lotion)
Report Number
DRDC-SUFFIELD-SL-2003-023 — Scientific Literature
Date of publication
08 Mar 2005
Number of Pages
9
Reprinted from
Journal of Applied Toxicology, vol 25, 2005, p 410-417
DSTKIM No
CA026456
CANDIS No
524317
Format(s):
Hardcopy;Document Image stored on Optical Disk

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