GB Toxicity Reassessed using Newer Techniques for Estimation of Human Toxicity from Animal Inhalation Toxicity Data: New Method for Estimating Acute Human Toxicity (GB)

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Authors
  1. Bide, R.W.
  2. Armour, S.J.
  3. Yee, E.
Corporate Authors
Defence R&D Canada - Suffield, Ralston ALTA (CAN)
Abstract
Estimated human inhalation toxicity values for Sarin (GB) were calculated using a new two independent (concentration, exposure time), one dependent (toxic response), non-linear dose response (toxicity) model combined with re-evaluated allometric equations relating to animal and human respiration. Historical animal studies of GB toxicity containing both exposure and fractional animal response data were used to test the new process. The final data set contained 6621 animals, 762 groups, 37 studies and 7 species.
Keywords
Chemical warfare agents;Human estimates;Sarin
Report Number
DRDC-SUFFIELD-SL-2002-190 — Scientific Literature
Date of publication
08 Mar 2005
Number of Pages
18
Reprinted from
Journal of Applied Toxicology, vol 25, 2005, p 393-409
DSTKIM No
CA026457
CANDIS No
524318
Format(s):
Hardcopy;Document Image stored on Optical Disk

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