Mass Spectrometric Determination of Chemical Warfare Agents in Indoor Sample Media Typically Collected during Forensic Investigations

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Authors
  1. D'Agostino, P.A.
  2. Hancock, J.R.
  3. Chenier, C.L.
Corporate Authors
Defence R&D Canada - Suffield, Ralston ALTA (CAN)
Abstract
Terrorist use of chemical warfare agents against civilian targets could involve the targeting of enclosed populated spaces. DRDC Suffield, in collaboration with the Royal Canadian Mounted Police, identified a need for analytical methods for chemical warfare agent identification in media, including flooring, wall surfaces, office fabrics and paper products, that would typically be collected in an office environment during forensic investigations. Typical office environment media were spiked at the 4 to 20 µg/g level with either a complex munitions grade sample of tabun (GA) or with a standard containing the three nerve agents, sarin (GB), cyclohexyl methylphosphonofluoridate (GF), soman (GD) and the nerve agent simulant, triethyl phosphate (TEP), to evaluate the potentials of LC-ESI-MS and LC-ESIMS/ MS for forensic purposes. The spiked chemical warfare agents were recovered with varying efficiencies, but in all cases sufficient chemical warfare agent was recovered for identification purposes. In some instances the aqueous extracts contained numerous coextracted sample components that complicated LC-ESI-MS analysis and hampered identification. These interferences were minimized during LC-ES-MS/MS analysis, where each of the chemical warfare agents was identified on the basis of acquired product ion mass spectra. MS data for all the spiked compounds in the nerve agent standard and the munitions grade tabun were acquired in the continuum mode with a resolution of 9000, which typ

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Keywords
Liquid chromatography;Mass spectrometry;Tandem Mass Spectrometry;Electrospray;Chemical warfare agents;Organophosphorus;Degradation products;Forensic science;Electrospray mass spectrometry;LC/ESI/MS
Report Number
DRDC-SUFFIELD-TR-2005-097 — Technical Report
Date of publication
01 Oct 2005
Number of Pages
44
DSTKIM No
CA026476
CANDIS No
524340
Format(s):
Hardcopy;CD ROM

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