DEVELOPMENT AND STANDARDIZATION OF DIAGNOSTIC ASSAY TECHNIQUES FOR INFLUENZA VIRUS

Authors
  1. Medzon, G.L.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN);University of Western Ontario, London ONT (CAN) Dept of Microbiology and Immunology
Abstract
The purpose of the study was to develop useful methods for studying the immune response in mice exposed to a lung infection. A model was developed to study the effect of a virulent mouse pneumotropic influenza virus (A/PR8/34) in mice in comparison with an avirulent egg-grown virus. These viruses correspond to a wild type virulent virus and an avirulent mutant. These viruses were used to study the immune response to live vaccine. It was found that both viruses, at appropriate doses, protected mice from a lethal intranasal infection if the vaccine was alive and delivered directly to the nose. Nasal spray, intraperitoneal injection and intragastric intubation gave less effective protection. The fact that the latter mode of vaccination was effective at all indicated a promising avenue of research for inducing mucosal immunity.
Report Number
DRES-CR-12/87 — Contractor Report
Date of publication
15 Jan 1987
Number of Pages
154
DSTKIM No
87-03672
CANDIS No
52460
Format(s):
Hardcopy;Originator's fiche received by DSIS

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