Development of a Novel Biomaterial: Part III. Stability and Hydration in Various Media

Développement d’un Nouveau Biomatériau: Partie III. Stabilité et l’Hydratation dans Divers Milieux

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Authors
  1. Peng, H.T.
  2. Martineau, L.
  3. Shek, P.N.
Corporate Authors
Defence R&D Canada - Toronto, Toronto ONT (CAN)
Abstract
This report describes the stability and hydration properties of gelatin and gelatin-HydroThane™ composite biomaterials in different media. A Gel permeation chromatography (GPC) method and swelling measurements were applied to examine the stability of the tested biomaterials. The degradation of gelatin in distilled water and 0.1% sodium azide aqueous solution was confirmed by the GPC study. The degradation in terms of changes in both molecular weight and its distribution was increased with increasing temperature. Samples of gelatin-HydroThane™ composite biomaterials were prepared by photochemical crosslinking of gelatin and HydroThane™ in dimethylsulfoxide solution under different conditions. Results of the stability and hydration studies in the aqueous solution demonstrated that the freeze-dried composite biomaterial exhibited relatively stable swelling for more than 30 days, but a loss of the gelatin component occurred, approximately by 10% at room temperature and 50% at 37°. Similar swelling study in a serum-containing medium indicated that the composite biomaterial would maintain the hydration stability for its potential application in a wound dressing. A number of key factors in the preparation of the biomaterial were investigated to optimize its hydration properties. The composite biomaterial showed good mechanical properties, primarily conferred by the more stable HydroThane™ component. The results of this study provide a better understanding of the physicochem

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Keywords
Hydrogel;Elastomer;Interpenetrating Polymer Network;Wound dressing
Report Number
DRDC-TORONTO-TR-2005-252 — Technical Report
Date of publication
01 Dec 2005
Number of Pages
75
DSTKIM No
CA026715
CANDIS No
524636
Format(s):
Electronic Document(PDF)

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