Development of a Novel Biomaterial: Part II. Evaluation of a Photo Cross-Linking Method

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Authors
  1. Martineau, L.
  2. Peng, H.T.
  3. Shek, P.N.
Corporate Authors
Defence R&D Canada - Toronto, Toronto ONT (CAN)
Abstract
This report describes the process for photo cross-linking the components of a biopolymer-elastomer interpenetrating polymer network (IPN) biomaterial for use as a wound dressing. Cross-linking of methacrylated gelatin was performed by ultraviolet irradiation in the presence of a photoinitiator. The yield and extent of the gelatin methacrylation reaction were quantified using various methods. Unexpectedly, we determined that HydroThane™ also cross-linked during the polymerization process, suggesting that a full IPN may be formed during the ultraviolet irradiation of the pre-IPN gelatin-HydroThane™ mixtures. Photo cross-linking of pre-IPN mixtures containing methacrylated gelatin and HydroThane™ produced films with desirable swelling ratios for our intended application. Several factors were examined for their contribution in determining the absorbency and/or mechanical strength of the films. These factors include: concentration of the photoinitiator; concentrations and component fractions of the different polymers; and, mixing conditions of the pre-IPN mixture. We also determined that antiseptic-loaded photo cross-linked IPN films remained bactericidal for up to 3 days. Lastly, the production of IPN films was scaled up to enable future in vitro and in vivo testing of IPN films. In summary, further development of the gelatin-HydroThane™ IPN biomaterial as a medicated wound dressing for treating deep, hemorrhagic cavity injuries sustained on the battlefield appears promis

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Keywords
interpenetrating polymer network;biopolymer;elastomer;hydration
Report Number
DRDC-TORONTO-TR-2005-201 — Technical Report
Date of publication
01 Dec 2005
Number of Pages
61
DSTKIM No
CA026721
CANDIS No
524644
Format(s):
Electronic Document(PDF)

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