Analysis of Chemical Warfare Agents: General Overview, LC-MS Review, In-House LC-ESI-MS Methods and Open Literature Bibliography

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Authors
  1. D’Agostino, P.A.
  2. Chenier, C.L.
Corporate Authors
Defence R&D Canada - Suffield, Ralston ALTA (CAN)
Abstract
Ratification of the Chemical Weapons Convention by more than 165 States Parties has reduced the risk of chemical warfare agent use, but there still remains a concern that other parties may make use of these weapons against civilian or military targets. Concerns within the defence and homeland security communities over possible terrorist use as well as the requirements for a verifiable Chemical Weapons Convention, have driven the development of analytical methods such as liquid chromatography-mass spectrometry (LC-MS) for the detection and identification of chemical warfare agents. This paper provides a general overview of chemical warfare agents and analytical methods for their analysis, a focused review on LC-MS applications, a summary of in-house LC-MS methods developed at DRDC Suffield, and a comprehensive bibliography of analytical open literature papers dealing with chemical warfare agent detection and identification.

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Keywords
Chemical warfare agents;FAIMS (Field Asymmetric waveform Ion Mobility Spectrometry);Electrospray LC-MS;Electrospray mass spectrometry
Report Number
DRDC-SUFFIELD-TR-2006-022 — Technical Report
Date of publication
01 Mar 2006
Number of Pages
90
DSTKIM No
CA027111
CANDIS No
525149
Format(s):
CD ROM

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