Liquid Chromatography Electrospray Tandem Mass Spectromic and Desorption Electrospray Ionization Tandem Mass Spectrometric Analysis of Chemical Warfare Agents in Office media Typically Collected During a Forensic Investigation

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Authors
  1. D’Agostino, P.A.
  2. Hancock, J.R.
  3. Chenier, C.L.
  4. Jackson Lepage, C.R.
Corporate Authors
Defence R&D Canada - Suffield, Ralston ALTA (CAN)
Abstract
Most prior analytical studies have dealt with the determination of chemical warfare agents in environmental or biological matrices that would typically be collected following battlefield use or in support of the Chemical Weapons Convention. These methods may be useful for some investigation, but may not be practical for indoor forensic investigations where chemical warfare agents use is suspected. There is a need for analytical methods for chemical warfare agents identification in office media, including flooring, wall surfaces, office fabrics and paper products, which would typically be collected in an office environment during forensic investigations. During this study, typical office environment media were spiked at the 4-20ug/g level with either a complex munitions grade sample of tabun (GA) or with standard containing the three nerve agents, sarin (GB), cyclohexyl methylphosphonofluoridate (GF), soman (GD) and the nerve agent simulant, triethyl phosphate (TEP), to evaluate the potentials of liquid chromatography electrospray ionization mass spectrometry (LC-ESI-MS) and liquid chromatography electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) for forensic purposes. An emerging technique, desorption electrospray ionization (DESI-MS/MS) was also investigated for the direct determination of TEP, GB and GD sample onto solid phase microextraction (SPME) fibers exposed to spiked office media. The spiked chemical warfare agents were recovered with varying
Keywords
Liquid chromatography;Electrospray ionization;Mass spectrometry;Tandem mass spectrometry;Desorption electrospray ioniozation;Chemical warfare agents;Workstations
Report Number
DRDC-SUFFIELD-SL-2005-190 — Scientific Literature
Date of publication
01 Oct 2005
Number of Pages
10
Reprinted from
Journal of Chromatography A, vol 1110, 2006, p 86-94
DSTKIM No
CA027158
CANDIS No
525196
Format(s):
Hardcopy

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