Evaluation of a Bi-Layer Wound Dressing for Burn Care I. Cooling and Wound Healing Properties

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Authors
  1. Martineau, L.
  2. Shek, P.N.
Corporate Authors
Defence R&D Canada - Toronto, Toronto ONT (CAN)
Abstract
Burn injuries remain a significant cause of morbidity and mortality despite the availability of numerous therapies. We assessed the wound healing and skin-cooling properties of a DRDC hydrogel/polyurethane wound dressing using different pre-clinical models. Our results show that 85% of partial-thickness, non-contaminated porcine wounds treated with our dressing healed within 6 days. In contrast, 85% of the wounds treated with commercial dressings healed within 8 days. Application of a moist DRDC dressing (to simulate a condition of exudate absorption) on a scald burn covering 25% of the dorsal area in rats reduced skin temperature by 1.70± 0.14°C for 5 min, the skin temperature being comparable to that of control burned rats after 20 min. The application of a moist DRDC dressing did not induce significant differences in body temperatures compared with that of burned animals without dressing coverage throughout the 90-min experiment. While no change in body temperatures were observed when standard dressings (i.e., not pre-moistened) were applied, skin temperature increased gradually. These data show that our dressing is effective in promoting faster healing of the treated wound; and providing a transient, but beneficial cooling effect to the skin contact-site, without the adverse effect of inducing whole-body hypothermia.
Keywords
Burn injury;hydrogel;partial-thickness wounds;skin cooling
Report Number
DRDC-TORONTO-SL-2005-112 — Scientific Literature
Date of publication
01 Jan 2006
Number of Pages
7
Reprinted from
Burns, vol 32, 2006, p 70-76
DSTKIM No
CA027612
CANDIS No
525603
Format(s):
Electronic Document(PDF)

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