A CRITICAL ANALYSIS OF THE USE OF THE CFK EQUATION IN PREDICTING COHb FORMATION

Authors
  1. Tikuisis, P.
  2. Madill, H.D.
  3. Gill, B.T.
  4. Lewis, W.F.
  5. Cox, K.M.
  6. Kane, D.M.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
Fifteen healthy young males, nine at rest and six at exercise, were exposed to high transient levels of carbon monoxide (CO) to simulate the breathing environment measured in an armored vehicle during weapons firing. Depending on the dosage, the CO exposures raised the subjects' carboxyhemoglobin saturation (%COHb) from 1.7% to 17.3%. The measured % COHb levels compared favorably (regression coefficient,b=1.04) to those predicted by the theoretical model of Coburn et al. When the application of this same model by a method proposed by NIOSH was used, however, a significant overprediction was found (b=1.28). It appears that this overprediction results primarily from the omission of water vapor in the lungs when the inspired pressure of CO is considered, and to the use of incorrect values for alveolar ventilation. TRUNCATED
Report Number
DCIEM-86-P-46 — Research Paper; Reprint
Date of publication
15 Mar 1987
Number of Pages
6
Reprinted from
American Industrial Hygiene Association J, vol 48, no 3, 1987, p 208-213
DSTKIM No
87-03896
CANDIS No
52680
Format(s):
Hardcopy;Originator's fiche received by DSIS

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